Abstract

Rajesh Gangwar*, Dr. C H V Rao

ABSTRACT

The objective of the study was to evaluate the effect of Murraya Koeingii on plasma glucose, insulin and C-peptide, blood hemoglobin and glycosylated hemoglobin, glycogen and carbohydrate metabolic enzymes in experimental diabetes in albino Wistar rats. Diabetes was induced by intraperitoneal injection of streptozotocin (45mg/kg) to albino Wistar rats. Murraya Koeingii(500 mg/kg and 1000 mg/kg) dissolved in 0.2% dimethyl sulfoxide was administrated orally to diabetic rats using an intragastric tube daily for a period of 35 days. A significant increase in plasma glucose, blood glycosylated hemoglobin and hexokinase activity and a decrease in plasma insulin and C-peptide, blood hemoglobin, glycogen (liver and muscle) and the activities of glucose-6-phosphatase and fructose-1, 6-bisphosphatase in liver and kidney were observed in STZ-induced diabetic rats. Oral administration of Murraya Koeingii restored all these biochemical parameters to near normal. Our present study clearly revealed that Murraya Koeingii possesses potent antihyperglycemic effect in STZ-induced diabetic rats.