Abstract

Mohd. Jalaluddin*1 Dr. Ravindra Chourasiya1 & Mohd Shafi Dar2

ABSTRACT

The present investigation is carried out for formulation and characterization of poloxamer stabilized Chitosan Nanoparticle for Control release and bioavailability to enhance the bioavailability of the poorly soluble drug Rivaroxaban by using different excipient which includes pre-formulation, formulation, optimization and characterization. Carrageenan-induced mice tail thrombosis. A total of 24 mice were randomly divided into 6 groups (n=6) and mouse were randomly distributed throughout groups. Group 1 served as control with Normal saline; Groups 3, 4 were, respectively treated orally with 20 mg/kg and equivalent to 20 mg/kg Rivaroxaban (RVRX) and RLNPs dissolved in 20% DMSO. Groups 2 was respectively injected with 100 IU heparin sodium as positive controls i.p. One hour after test samples were administered intraperitoneally, each mouse was injected with 40 ?l (1%) carrageenan dissolved in physiological saline by intraplantar administration in the right hind paw. The results of the carrageenan-induced mice tail thrombosis at different time interval were mentioned in the above table. According to the observed results both RVRX as well as RLNPs having good anti- thrombosis activity. It was found that RVRX (63.33 %) showed significant inhibition of the thrombosis as compared to the RLNPs (68.64 %). These findings may contribute to the successful development of new pharmaceutical formulation F7 and may use as a better agent in the drug delivery system as well as can have used in the treatment area of cardiovascular diseases.