Abstract

Anup K. Chakraborty, Alka Singh, Parmeshwar B. Shinde

ABSTRACT

An efficient route of synthesis of some new Aryloxypropanolamine derivatives was proposed and Anti-diabetic activity. In this research paper, Aryloxypropanolamine derivatives were synthesized via three step process. In the first step, imine intermediate was obtained (S1 to S5) and in the second step, oxirane intermediates were obtained (E1 to E5) and finally Aryloxypropanolamine derivative was obtained (A1 to A5). The blood sugar level was monitored at specific interval there was a good decrease in the elevated levels of the blood glucose in 6 hours study after oral ingestion of the standard as well as test drug. The synthesized aryloxy propanolamine derivatives had shown better anti-diabetic activity. Among the five synthesized derivatives, A5 shows potent and significant anti-diabetic activity as compared to other derivatives.