Abstract

Sajal John, Murtuza Zaki, Dr. Rita Mourya, Dr. Shailesh Jain

ABSTRACT

Tablet manufacturing represents one of the most widely used dosage forms in pharmaceutical industry, accounting for approximately 70% of all solid oral dosage forms. Quality control parameters are essential for ensuring the safety, efficacy, and consistency of tablet products throughout the manufacturing process. This comprehensive review examines the critical quality control parameters employed in tablet manufacturing, including pre-compression, compression, and post-compression testing methodologies. Key parameters discussed include particle size analysis, flow properties, moisture content, tablet hardness, friability, disintegration time, dissolution profiles, content uniformity, and weight variation. The review also addresses modern analytical techniques, process analytical technology (PAT), and regulatory requirements governing tablet quality control. Understanding and implementing robust quality control systems is crucial for pharmaceutical manufacturers to comply with regulatory standards and deliver consistent, high-quality products to patients.