Abstract

Rakesh Kumar Mahato, Shweta Gogate, Dr. Rita Mourya and Murtuza Zaki

ABSTRACT

Background: Medication non-adherence represents a critical challenge in chronic disease management, contributing to poor health outcomes, increased healthcare costs, and elevated mortality rates. Despite advances in pharmacotherapy, suboptimal adherence rates persist across various chronic conditions. Objective: This review synthesizes current evidence on medication adherence strategies in chronic disease management, examining their effectiveness, implementation challenges, and clinical outcomes. Methods: A comprehensive literature review was conducted examining peer-reviewed articles published between 2018-2024 focusing on medication adherence interventions in chronic diseases including diabetes, hypertension, cardiovascular disease, and mental health disorders. Results: Multiple evidence-based strategies demonstrate efficacy in improving medication adherence, including patient education programs, technology-enabled interventions, healthcare provider training, pharmaceutical care services, and policy-level modifications. Multicomponent interventions show superior effectiveness compared to single-strategy approaches. Digital health technologies, particularly mobile health applications and electronic pill dispensers, show promising results with adherence improvements ranging from 15-40%. Conclusions: Successful medication adherence improvement requires a multifaceted approach combining patient-centered care, technology integration, healthcare system modifications, and policy support. Healthcare providers should implement tailored, culturally appropriate interventions based on individual patient needs and barriers.