Abstract

Arjun Gupta, Shweta Gogate*, Shailesh Jain and Rita Mourya

ABSTRACT

Paracetamol is an analgesic and antipyretic drug which are generally used in reducing fever and relief in pain. PCM is one of the popular OTC products among patients. In this time all the pharmaceutical companies produce various brands of paracetamol tablets by various technique and manufacturing process. The aim of the study is to compare and evaluate different brands of paracetamol tablets of 500mg. Three different brands of paracetamol 500mg were taken in this research work to check their quality control parameters like weight variation, hardness, friability, disintegration and dissolution test. These brands are manufactured by multinational companies and local companies. Acceptable & wearable Weight variation and friability are seen in all brands. The physical and chemical tests like in-vitro dissolution, disintegration, hardness etc. were found to be varying but within the specified limits. At the point of conclusion, local brands of Paracetamol are found to be safe enough and will use to achieve desired therapeutic effect.