Abstract

Saba Rana, Vikas Kumar, Ankit Kumar, Vipin Kumar Saini, Zehra Husaini, Girendra Kumar Gautam*2

ABSTRACT

The research paper investigates the biochemical and insulin resistance profiles in Type 2 Diabetes Mellitus (T2DM) patients compared to healthy individuals. The study involved 200 subjects, with 100 in each group. Significant elevations were observed in fasting blood sugar (FBS), glycosylated haemoglobin (HbA1c), and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) in diabetic subjects compared to healthy controls. Dyslipidaemia markers such as triglycerides (TG), very low-density lipoprotein cholesterol (VLDL-C), and low-density lipoprotein cholesterol (LDL-C) were notably elevated, while high-density lipoprotein cholesterol (HDL-C) was diminished in diabetic subjects, indicating an increased cardiovascular risk. Insulin resistance was markedly higher in diabetic subjects, emphasizing its role in T2DM pathogenesis. These findings stress the importance of comprehensive management strategies targeting glycaemic and lipid control to mitigate complications in T2DM patients.