Abstract

Bindu Jain, Susmita Uppugalla*, Arin Bhattacharya, Anita D. Dubey, Bharti Patel

ABSTRACT

Chalcone derivatives have an alpha,beta-unsaturated carbonyl group linking a phenylketone backbone to an aryl or heteroaryl ring. Claisen-Schmidt condensation, aldol condensation, and oxidative coupling processes may synthesise them, which are found everywhere. The unusual molecular structure of chalcone derivatives gives them fluorescence, UV-Vis absorption, and electrochemical characteristics. Due to their conjugated double bond system, chalcones are yellow to orange and exhibit a UV-Vis absorption peak at 400-450 nm. Due to their various pharmacological characteristics and therapeutic potential, chalcones have garnered interest in drug research and development. 1. Review chalcone derivative chemistry, including synthesis, chemical changes, and SAR investigations. 2. Discuss the anti-inflammatory, anti-cancer, antibacterial, and antioxidant effects of chalcone derivatives and their modes of action. 3. Discuss the therapeutic uses of chalcone derivatives in different illnesses and disorders and their medication development status. 4. Identify important obstacles and possibilities in this subject and propose future research and development. The technique used to synthesise chalcones relies on starting materials, reaction circumstances, product yield, and purity. Based on the synthesis's needs, choose a technique that has pros and downsides. Structure-activity relationship (SAR) investigations of chalcone derivatives show that chemical structure strongly affects biological activity. Chalcones' pharmacological effects depend on the derivative and target cell or tissue. Chalcones affect several signalling pathways and biological targets for their pharmacological effects. In preclinical research, chalcone compounds showed intriguing pharmacological properties, although none are licenced for clinical use. Some chalcone compounds are in clinical studies for different reasons.