Abstract

Dr. K. Hemamalini*, P. Navyabala1, B. Varalaxmi1, K. Bhargavi1, M. Lavanya1, T. Naveen1

ABSTRACT

This article presents the anti-inflammatory activities of natural products. Many review articles were published in this regard; Moreover, this review pinpoints some interesting traditionally used medicinal plants that were not investigated yet. The egg white was used to induce rat paw inflammation, with inadequate references to explain its mechanism. It's contained protein was identified as an allergen was suspected to trigger an inflammatory reaction. This research was aimed to evaluate the use of egg white as an inflammatory inductor in inflammation animal models through edema profile and histological change. Male Wistar rats were divided into three groups, which were given fresh takes of the hen's egg white, and sterile saline solution. Edema was induced by subcutaneous injection of 0.1 ml of (1%), egg white, and sterile saline solution as the control in the hind paw of rats. Paw volume was measured before and then at 1, 2, 3, 4, 5, 6, and 24 h after the inductor injection. The data were analyzed by one-way ANOVA followed by TURKEY test. The results of the study showed that the egg white could induce rat paw inflammation. Edema formation began in the 1st h and reached the peaks in the 2nd h after the subcutaneous injection of egg white. Egg white was potential as an edema inductor for animal models of inflammation for the evaluation of new drugs or natural product with anti-inflammation activity. The plant extract at a dose level of 300 mg/kg was used as a test drug showed a significant anti-inflammatory activity when compared to that of the standard drug indomethacin.