Abstract

Asha Tiwari, Dr. Rajesh Mujariya

ABSTRACT

Recently European Pharmacopoeia also adopted the term “Oro Dispersible Tablet” defined as uncovered tablet for buccal cavity, where it disperses before ingestion”. Fast disintegrating tablets (FDT) are also known as fast dissolving, mouth dissolving, rapiddissolve, quick d isintegrating, orally disintegrating, fast melts, Oro dispersible, melt-inmouth, quick dissolving, porous tablets, Effervescent Drug Absorption System. Fast disintegrating tablets are those when put on tongue disintegrate instantaneously releasing the drug which dissolve or disperses in the saliva. When faster the drug into solution, quicker the absorption and onset of clinical effect. Some drugs are absorbed from the mouth, pharynx and esophagus as the saliva passes down into the stomach. In such cases, bioavailability of drug is significantly greater than those observed from conventional tablets dosage form. The advantage of mouth dissolving dosage forms is increasingly being recognized in both, industry and academics. The basic approach in development of FDT is the use of super disintegrants like cross linked carboxy methyl cellulose (croscarmellose), sodium starch glycolate (primogel, explotab), cross linked polyvinylpyrrolidone (crospovidone) etc., which provide instantaneous disintegration of tablet after putting on tongue, thereby release the drug in saliva. The bioavailability of some drugs may be increased due to absorption of drug in oral cavity and also due to pregastric absorption of saliva containing dispersed drugs that pass down into the stomach. Moreover, the amount of drug that is subjected to first pass metabolism is reduced as compared to standard tablet. The target populations for these new fast disintegrating dosage forms have generally been pediatric, geriatric, and bedridden or developmentally disabled patients.