Abstract

Neha Yadav*, Sachin Kumar Jain, Neetesh Jain

ABSTRACT

The most prevalent illness with a high contagiousness profile and the leading cause of death from infectious agents is tuberculosis. The emergence of Mycobacterium TB drug-resistant strains and the sharp rise in tuberculosis infection rates globally demonstrate the pressing need for the creation of novel, potent drugs for the treatment of tuberculosis. Given that several derivatives of benzimidazoles, such as those containing electron-withdrawing groups, have already been shown to have antimycobacterial action, they constitute one potential source of novel molecules. In the present work, a series of new benzimidazole derivatives were synthesized from Schiff’s bases using different aromatic aldehydes. The structures of these compounds were confirmed by IR, NMR, Mass, and elemental analysis. The synthesized compounds (BID1- BID5) were screened for anti-tuberculosis activity against Mycobacterium tuberculosis and the results show that some of these derivatives possess good activity against Mycobacterium tuberculosis.