Abstract

Dr. S. M. Shahidul Islam, Sabina Yasmin, Dr. Boxu Lang

ABSTRACT

Motor neuron diseases (MNDs) are a group of rare neurodegenerative disorders that selectively affects motor neurons frequently termed amyotrophic lateral sclerosis (ALS). To put it another way, respiratory failure is the most prevalent cause of death from increasing muscle weakness and bulbar dysfunction. Until all of the clinical signs and symptoms are present, it may be difficult to confirm the diagnosis. [1] All varieties of the condition have a large differential diagnosis to consider, including curable illnesses, so a professional neurology opinion should always be acquired. Even if only a tiny number of persons with familial ALS can be proved to have a definite genetic inheritance, research into the molecular basis of genetic subtypes is generating critical insights that could one day lead to medicines for sporadic occurrences of the condition.[2] When there is no cure or disease-modifying medication, care is supportive and comprises a multidisciplinary team. Complex hereditary and environmental variables may play a role in the development of motor neuron disease, and future therapy may include a mix of molecular medicines or stem cell transplants to restore cell integrity. Patients with MND or ALS suffer from a progressive degenerative condition that has no identifiable etiology. It is important to think about the distinct forms of motor neuron disorders in terms of the relative involvement of upper and lower motor neurons when evaluating the differential diagnosis.