IN VITRO AND EX VIVO ANTI-CLOTTING ACTIVITY OF FEW 1,3,4-OXADIZOLE DERIVATIVES
Dr Girendra Kumar Gautam
ABSTRACT
Oxadiazole is thought to be produced from furan by substituting two pyridine type nitrogen (-N=) groups for the methane (-CH=) group. Compounds with the 1,3,4-oxadiazole nucleus have been tested for antiinflammatory, analgesic, antithrombotic, anticancer, anticonvulsant, antioxidant, and herbicidal properties. These include factors V, VII, VIII, XI, and XIII. Both the extrinsic and intrinsic pathways converge at this point. The prothrombin time is a clinical indicator of the extrinsic pathway. The liver is one of the organs involved in the coagulation process. Factors I, II, V, VII, VIII, IX, X, XI, and protein C and S are all produced in the liver. Fresh frozen plasma is used to treat coagulopathy in patients with liver disease. 500ul of streptokinase (30000IU) was used as a positive thrombolytic, and 100ul of PBS as a negative control. The order of the in vitro clot lysis effect of all investigated compounds is 3i>SK>3e>3a>3h>3g>3b>1>3c, which is consistent with the results of the previous studies.
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