Abstract

Asha Tiwari, Dr. Rajesh Mujariya, Dr. Manjeet Singh, Gaurav Verma

ABSTRACT

Fast dissolving drug delivery have gained significant appeal and acceptability as innovative drug administration methods, owing to their ease of use and patient compliance. Patients' low acceptability and compliance continue to drive the demand for non-invasive delivery solutions. In the GI tract, uterus, major blood arteries, and airway smooth muscle, desloratadine compete with unbound histamine for binding to H1-receptors. The goal of this study was to create and formulate Desloratadine fast-dissolving tablets. Fifteen sets of formulation were made with an exactly weighed amount of drug-resin complex combined with various proportions of super disintegrant (1.5 percent, 3 percent, 4.5 percent, 6 percent, 7.5 percent) (Sodium starch glycolate, Crospovidone, Croscarmellose Sodium). The formulation was tested for thickness, hardness, wetting time, friability, and other factors. In addition, the compositions were tested for in vitro disintegration and dissolution times. In vitro dissolving tests revealed that all formulations released more than 90% of the medication after 10 minutes. 7.5 percent Crospovidone (F-10) showed the greatest increase in dissolving rate among all formulations. Within 10 minutes, 97.12 0.37 percent of the product was released. The best formulation was discovered to be F-10, which had a shorter disintegration time and higher drug release.