Abstract

Vinod Kumar Rajak, Rajesh Kumar Pal, Dr. U. S. Sharma, Pawan Sharma, Maneesh Krashna

ABSTRACT

Aim & object- Musa acuminate has been shown to be hepatoprotective by Indian traditional medicinal system but has not been pharmaceutically approved or evaluated.so the present research work was done to explore the hepatoprotective activity of Musa acuminate against experimentally induced hepatotoxicity in Wistar rats. Aim of the study- To identified and scientifically proved the hepatoprotective activity of Musa acuminate. Materials and methods- Albino Wistar rat weighing 120-150 g of either sex divided into six groups of six animals each. Group 1 was the control group taking distilled water and a common diet that was given to all other groups. Group 2-carbon tetrachloride 1%v/v olive oil 1mg/kg/BW i.p. injection twice a week. group3- Musa acuminate extract 50% (methanol:h2o) 250 mg/kg/BW by oral route.+corbon tetrachloride 1%v/v olive oil 1mg/kg/BW i.p. injection twice a week. group4 - Musa acuminate extract 50% (methanol:h2o) 500 mg/kg/BW by oral route + carbon tetrachloride 1%v/v olive oil 1mg/kg/BW i.p. injection twice in a week . group 5 - Musa acuminate extract 50% (methanol:h2o) 250 mg/kg/BW by oral route alone.group 6- Musa acuminate extract 50% (methanol:h2o) 500 mg/kg/BW by oral route.were estimated. Blood was collected from anesthetized animals. ALT, alanine aminotransferase; ALP, alkaline phosphatase; AST, aspartate aminotransferase; ALB, albumin; TP, total protein; MDA, malondialdehyde were estimated. Results – ALT, ALP & total protein levels were significantly increased in CCL4 treated group while Musa acuminate displayed a significant reduction in rising in these parameters. Conclusion – It can be concluded from the present study that musa acuminate root extract is a potent hepatoprotective agent .it is assumed that this hepatoprotective effect of musa acuminate may be due to several reasons such as antioxidant and or free radical scavenger property and ability to induce hepatic regeneration.